A while back we had our work machines upgraded (and I will blog about it ;)). I now look at a 4096×1192 desktop while I work. That’s two very wide Samsung monitors side by side.
Initially I worked with four applications tiled vertically across the workspace. This was very efficient. However, I do a lot of work just using the browser. So a few Firefox extensions and a vertical re-haul later and I’m in business :D
So here’s what I’m doing. First thing I did was switch the Windows task-bar vertically to the left-hand side of the workspace. Because I’ve got so much width, I can easily afford a generous sized task-bar now. I’ve got the task-bar at approximately 96px wide. I can clearly read the titles of at least 24 application tabs with 18 32px icons attached as well. It’s daunting at first, and I still look at the bottom right for the time, but it’s certainly much more efficient. My only gripe is the start menu doesn’t invert with the task-bar, so when you press it you have to navigate to the bottom to find “All programs”.
Setting up Firefox wide was pleasurable. I use Personal Menu to eliminate the menu-bar from the top, essentially hiding the menu-bar (like Internet Explorer and Chrome). Although I’ve got a good height, applications and websites will always scroll down, so having a few extra pixels really helps. (Don’t get me started on stupid side scrolling website :P)
For the tabs, I use Tree Style Tabs. It’s a beautiful add-on that sorts out tabs in a hierarchy, making them easily manageable. By default, it groups them and collapses the tree when out of focus, but I’ve disabled this as it would take me about 60 tabs to get that far :P
I can see the title of each tab very clearly. Because I’ve got sooo much width (brag brag brag eh?) I also keep the bookmarks side-bar always open.

So to conclude: when I’m working, because I’ve got so much width, I have adjusted my desktop and Firefox to use vertical menus and tool-bars, instead of the horizontal by default. At home, I’ll still use Chrome, because I haven’t got the width and I can always scroll for more height. The point is I still don’t have to side-scroll.
Vertical tool-bars and wide screens – it’s the future :P